Thanks for the tips both of you. Tim, on Windows 10 you can go to Settings, then Connected Devices, and the CI-1 shows up under the connected USB devices as "CI-1". From there you can click on it to remove the device from Windows, which I've done. I plug it back in and it automatically re-installs the drivers will pop back up in the list as expected.
Alan, I've also tried all the USB ports (only three of them, all USB 3.0 which the CI-1 is compatible with). The USB ports all seem to be working properly, as I have used each of them with many different devices. All the drivers on the USB ports are fully updated as well.
My only other thought is a possible issue with the install of the HC Sim program, but I've deleted and reinstalled it several times. This includes deleting the hidden folder under ProgramData.
I really don't think this is a problem with the HC Sim software or CI-1. As I said earlier, I plugged the CI-1 into my desktop and loaded the HC Sim, and everything works flawlessly as expected. Just something with my laptop I guess.
-Kevin