I've started an install on an Athearn (Southern Pacific) U50. I'll update this post as I move forward.
After removing the shell, I removed Athearn's stock PC board and all grain-of-wheat light bulbs. I will replace the bulbs with LED's. Note - I use 15 mA or 20 mA LED drivers with the LEDs as opposed to resistors.
Here's a photo of the stripped down chassis.
There is a grey wire coming from each of the four trucks on each side providing track power, so four wires per side for a total of eight. You can see them sticking up in the above photo.
Next, I cut a piece of PCB bread-board to make it simpler to connect all of the wires. In addition to the normal forward/reverse headlights, I'm going to install SP's typical oscillating headlight. Here's a picture of that PCB board installed. Note that I cut-out a couple notches into it to fit around the screw posts that held the factory PCB.
Here's a close-up of the PCB. Here I've soldered the track power leads to separate chases on the PCB. I've separated them by one PCB chase just to help insure no adjacency shorts. I also fed the blue and orange motor wires up through the PCB.
I plan to install the LM-3S just forward of the PCB.
The Scale Sound Systems paired speakers are also installed at this point. One conveniently uses a pair of screw posts that held the original factory PCB. The one in the rear is bigger and sits on the chassis frame with a piece of double-sided tape. I plan to wire these in series.